The Role of Interleukines in Asthmatic Patients

Hassan A.Al-Saadi * and Muhamed Salih Mahdi**
B.Sc.,M Sc. ,Ph D. (Immunology)
*Department of Clinical Laboratory Sciences/College of Pharmacy /University of
**M.B.Ch.B F.I.B.M.S(Immunology) / Department of immunology / Al-Hussein
teaching hospital /Kerbala health directorate
(K . J . Pharm . Sci)
(Received July 2011 , Accepted Nov. 2011)

Background: Asthma is a chronic inflammatory disease of the airways because body exposure to foreign materials that stimulate immune response characterized by secretion of cytokines from inflammatory cells.
Objective: Diagnosis of asthma to detect about IgE,IL 1B,IL 2IL 8,,IL10 ,and IL12 in patients clinically suspected . Patients and Methods:50 blood samples out patients were collected in a labeled 5 ml tubes,aged (26 years to 58 years ) were tested by Enzyme Linkined Immuno Sorbant Assay to detect IgE,IL 1B,IL 2IL 8,,IL10 ,and IL12 were carried in Al-Hussein Hospital in Kerbala ,during the period from May to Augest 2010.
Results:50 patients were evaluated for asthma and correlation between IL 1B,IL 2,IL 8,IL 10 ,IL 12 values (20,76,62,44,76)% respectively and IgE value (50)%.Increasing values of IL2,IL 8,IL 10,IL 12 (36,26,24,32)%respectively at ages(37-47)years were led to decreased IgE value(10%),and IL 2,IL 8 values were (24,22)% respectively comparion
with IgE(10%).
Conclusions: Importance studying factors( IL 1B,IL 2,IL 8,IL 10 ,IL 12) in diagnosis of Asthmatic patients after clinically diagnosis .