Abd, Radhiah Najim
College of applied medical sciences /university of Karbala
Abstract:
The present work seeks to examine the histopathological changes in kidney, lung and Liver tissue of mice which exposed to lead acetate. Sixteen healthy mouse were divided into four groups each group of four animals and the first group was kept as un-medicated control while, the second, third and fourth groups were given Lead acetate at a dose of 18 mg/kg for one, two and three weeks respectively Lead acetate was given by oral route. In the experiment’s end, the exposed mice with LA were sacrificed and the main target tissues such as kidney, lung and liver were collected for histopathological study. The results of this study proved that kidney lesions shows congestion, degeneration and mild chronic inflammation compared with control group. The lung histopathological alternates shows moderate congestion, mild mixed inflammation and hemosidren deposition. As well as the changes in liver showing lobular disarrangement, congestion, moderate portal and lobular hepatitis was also observed. the present study proved that heavy metal containing lead have toxicological effects on the target organs.
