ABSTRACT
We compared between the hypolipdemic effect of methanolic extract of Moringa oleifera leaves and exogenous ghrelin in atherogenic rats. This study was conducted on (n = 50) Albino Wistar male rats (200-250) g, ages were range of (10-17) weeks, in laboratory of animal physiology of science collage/ university of Kufa. The animals were distributed into ten groups (G1-G10) including 5 animals each. Groups G1 fed a standard diet, G2 fed an atherogenic diet, G3 administered 250 mg/kg of M. oleifera and atherogenic diet, G4 administered atherogenic diet and 250 mg/kg of M. oleifera, G5 administered 500 mg/kg of M. oleiferaand atherogenic diet, G6 administered atherogenic diet and 500 mg/kg of M. oleifera, G7 administered 100 μg/kg of ghrelin and atherogenic diet, G8 administered atherogenic diet and 100 μg/kg of ghrelin, G9 administered 300 μg/kg of ghrelin and atherogenic dietand G10 administered atherogenic diet and 300 μg/kg body weight of ghrelin. Dyslipidaemia induced by atherogenic diet for 60 days. Two concentrations of Methanolic leaf extract of M. oleifera and exogenous ghrelin administered before and after 2 hours of atherogenic diet. The serum concentration of total cholesterol, triglyceride (TG), LDL-C, VLDL-C, HDL-C, and body weight and organs weight were estimated in control, non-treated and treated animals groups. The results revealed significant increase (P≤0.05) in serum Cholesterol, TG, LDL-C, VLDL-C levels and significant decrease (P≤ 0.05) in serum HDL-C levels in atherogenic groups in comparing to control group. The results also revealed significant decrease (P≤0.05) in serum Cholesterol, TG, LDL-C, VLDL-C levels and significant increase (P≤0.05) serum HDL-C levels in atherogenic groups administered methanolic extract of M. oleifera leaves and ghrelin hormone compared to atherogenic group. The results also revealed significant increase (P≤ 0.05) in body weight and Kidney, liver and heart weight in atherogenic groups in comparing with control group. The results also showed significant decrease (P≤ 0.05) in body weight and weight of kidney, liver and heart in atherogenic groups administered methanolic extract of M. oleifera leaves and ghrelin hormone compared to atherogenic group.no differences between the effects of methanolic extract of M. oleifera leaves and exogenous ghrelin hormone on different study parameters estimated.
Keywords: Moringa oleifera, Ghrelin, Atherogenic diet, obesity.
