ABSTRACT
Aim: This research aimed to investigate whether endothelial nitric oxide synthase of eNOS intron 4
polymorphism and ACE gene I/D polymorphism have a role in the enhancement of the progressive of ADPKD
with regards to hypertension. Materials and Methods: The research was executed on 50 members with
ADPKD presented in some dialysis centers in Baghdad city/ Iraq and 50 similar age healthy controls individuals.
The eNOS gene polymorphisms (intron 4 VNTR 4a/b) and ACE gene polymorphism were determined by the
polymerase chain reaction method. Results: In the current research shows the ACE gene polymorphism is
independent factors for hypertension in the ADPKD patients with high significant factors (DD p<0.001); also
for eNOS intron 4 gene polymorphisms were expressively different between ADPKD patients whose with
hypertensive and whose with normotensive (4a p<0.001). Conclusion: This research investigated that ACE
and eNOS gene polymorphisms are associated with ADPKD patients concerning hypertension. For future
studies, it must investigate other gene polymorphisms that responsible for hypertension to reveal the relation
effect on the progressive of ADPKD.
Keywords: eNOS gene, ACE gene, ADPKD, Hyper ten
