Toxic Effects of Prolonged Ni (II) and Cr (VI) Exposure in Male Mice on
Bone Marrow and Some Hematological Parameters
Abeer cheaid yousif AL-fatlawi
Faculty of applied medical sciences, university of Karbala, Iraq.
Keywords: heavy metals, Ni and Cr elements, hematological parameters , bone marrow.
Received (August) , Accepted (June)
Abstract
Heavy metals hazard which can causes toxicological effects on many organs in animals and
humans, therefore the purpose of the present study was to investigated the pathological lesion
of Nickel (Ni II) and Chrome (Cr VI) metals on some hematological parameters in which
heavy metal causes disorder in hematopoietic cell renewal system, which the results showed
significant decrease (P≤0.01) in the red blood cells (RBC) count for all doses of Ni and Cr
elements, significant decrease (P≤0.05) in the monocytes cell counts only at intermediate and
high dose of Ni and Cr elements while significant increase (P≤0.01) of granulocytes cell
counts only at high dose for both Ni and Cr elements. Although the results demonstrated there
was no any significant difference on platelets for all doses of Ni. On other hand no any
significant difference on platelets only at the lowest dose of Cr while, high significant
differences (P≤0.01) on platelets at both intermediate and high dose of Cr. Also the results
showed significant decrease (P≤0.05) in the bleeding time and clotting time for all groups
treated with different doses of both Ni and Cr elements. Dramatic histological lesion for both
elements found in the tissue of bone marrow such as degenerate, necrotic and loosely
arranged of tissue
