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Galangin and Gold nanoparticles as novel anti-tumor
therapy via induction of apoptosis in MCF-7 and
AMN-3 cell lines

 

Abstract
Galangin (3, 5, 7-trihydroxyflavone) is a flavonoid
from the root of Alpinia officinarum. It has anti breast
cancer properties. In the current study, AMN3 and
AMF-7 were treated with galangin alone, galangin
combined with Gold nanoparticles (GNPs) and GNPs
alone and anti-proliferative activity of these substances
was studied using MTT assay. The expression of p53,
caspase-8 and caspase-9 genes was investigated using
PCR technique. Galangin concentrations were used at
different concentration 5, 10, 25, 31.25, 62.5, 100, 125,
250 and 500 μg/mL. GNPs concentrations was
6.25,12.5, 25, 50 and 100 μg/mL. The results of gene
expression showed significant effects on p53, caspase
8 and caspase 9 in MCF-7 cell line, and AMN-3.
Galangin combined with gold nanoparticles exhibited
the best IC50 on MCF-7 and AMN3 with strong gene
expression of p53, caspase-8 and caspase-9.

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