SUMMARY
Eighteen adult female were divided into three equal groups (6/ group) and were treated for one month as follows: first group (control ) G1,which were intubated ordinary tap water, second treated group (G2) , animals in this group were intubated orally with 100mg / kg B.w of methionine for one month ,while the third group(G3) were handled in G2 plus oral intubation of folic acid (0.07mg / kg B.w ). fasting blood samples were collected each 10 days for measuring Estrogen hormone, Electro cardio graphy was recording for rabbits after each 10 days of treatment .The results conducted that Asignificant increas(P<0.05)in Esterogen hormone concentration and a significant decrease ( p<0.05) in heart rat and a significant increase (p<0.05) in QRS and QT interval in (G2) . While treatment of animals with folic acid caused a significant increase (p<0.05) in heart rat and a significant decrease (p<0.05) in Esterogen hormone concentration and QRS and QT interval in (G3).
