ABSTRACT
This study was conducted on (n = 40) Albino Wistar male rats (200-250) g, ages were range of (10-17) weeks, in laboratory of animal physiology of science collage/ university of Kufa. The animals were distributed into eight groups (G1-G8) including 5 animals each. Groups G1 standard diet for two months, G2fed a standard diet for three months,G3 fed an atherogenic dietfor two months, G4 fed an atherogenic diet for three months, G5 administered atherogenic diet and 250 mg/kg of M. oleifera for two months, G6 administered atherogenic diet and 250 mg/kg of M. oleifera for three months, G7 administered atherogenic diet and 500 mg/kg of M. oleiferafor two months, G8 administered atherogenic diet and 500 mg/kg of M. oleiferafor three months. obesity induced by atherogenic diet for two and three months. The serum concentration of ghrelin, obestatin, and VEGF were estimated in control, non-treated and treated animals groups. Theresults revealed significant increase (P≤0.05) in serum obestatin, and VEGF levels and significant decrease (P≤ 0.05) in serum ghrelin in obese groups in comparing to control group.The results also revealed significant decrease (P≤0.05) in serum obestatin, and VEGF levels and significant increase (P≤0.05) serum ghrelin levels in atherogenic diet groups administered methanolic extract of M. oleifera leaves compared to obese group. The present study concluded the good effect of M. oleifera by both concentrations on altered biochemical markers induced by atherogenic diet.
Keywords:Moringa oleifera, Ghrelin,obestatin, VEGF, Atherogenic diet, obesity.
