Abstract
Bisphenol A (BPA) is one of the manufacturing compounds. The present study was conducted to investigate effect of BPA on some biochemical and
hematological parameters such as Alanine Aminotransferase (ALT), Aspartate Aminotransferase(AST) Glucose, Red blood cells (RBCs), Hemoglobin (Hb),
White blood cells (WBCs) and differential WBCs. Twenty four female rats were used and divided into three groups (8 animals for each group) randomly. Animals of first group was negative control group and second group was positive control group received normal saline and corn oil orally respectively,while female rat of third group were received BPA suspended with corn oil (250mg/kg B.W/day) orally as treatment group for 30 days . Results of the present study revealedsignificant increase (P≤0.05) in serum level of ALT, AST, Glucose, WBCs counts and percentage of neutrophil but there is significant decrease (P≤0.05) in RBCs counts, Hb concentration and percentage of lymphocyte in group administrated BPA in compared with control groups,while there are non significant changes in percentage of monocyte, eosinophil and basophilFrom the results of the present study, it was concluded thatBPA leads to occurred negative results on hematological and biochemical parameters.
Keywords
Bisphenol-A-, ALT, AST, Rat.
