Research - Applied Medical Sciences https://ams.uokerbala.edu.iq/wp/en Wed, 07 Jun 2023 08:25:14 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.4 Evaluation of leptin serum concentration in cases of blood transfusion dependent Beta thalassemia and its relationship with thyroid dysfunction https://ams.uokerbala.edu.iq/wp/en/blog/2023/06/07/evaluation-of-leptin-serum-concentration-in-cases-of-blood-transfusion-dependent-beta-thalassemia-and-its-relationship-with-thyroid-dysfunction/ Wed, 07 Jun 2023 08:18:02 +0000 http://ams.uokerbala.edu.iq/wp/en/?p=8141 Evaluation of leptin serum concentration in cases of blood transfusion dependent Beta thalassemia and its relationship with thyroid dysfunction ABSTRACTIntroduction and Aim: Thalassemia disorder is characterized by the body’s inability to produce hemoglobin. This is an inherited disorder and arises due to defects in one or more globin chains. Thalassemia patients have been associated with […]

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Evaluation of leptin serum concentration in cases of blood transfusion dependent Beta thalassemia and its relationship with thyroid dysfunction

ABSTRACT
Introduction and Aim: Thalassemia disorder is characterized by the body’s inability to produce hemoglobin. This is an inherited disorder and arises due to defects in one or more globin chains. Thalassemia patients have been associated with endocrine dysfunction leading to toxic and deleterious effects. In the present study, we aimed to correlate leptin levels in Transfusion-dependent beta-thalassemia (TDT) patients to their thyroid hormonal levels and hematological parameters.
Materials and Methods: The study included 50 individuals (25 male and 25 female) aged 11-20 years with beta-thalassemia major and 20 healthy individuals (10 male, 10 females) aged 13-20 years as controls. All individuals included in the study were assessed for their BMI, complete blood count, serum ferritin and iron, thyroid function, leptin and ghrelin hormonal levels.
Results: This study showed a low BMI in patients as compared to healthy individuals. A high increase in TSH and ferritin was found in patients of both genders as compared to controls. T4 significantly decreased in males and females as compared to control. Significant reduction in leptin levels was observed in both male and female patients. A positive correlation was observed between leptin and TSH in males while a negative correlation between leptin and T4 was observed in females. A significant positive correlation was seen between leptin and T4 and between TSH and T4. BMI in males and female significant low compared to control.
Conclusion: Leptin probably plays an important role in thyroid dysfunction. Serum leptin, ferritin and thyroid hormonal levels in patients could be used as a guide in predicting hormonal modulation in major beta thalassemic patients.
Keywords: Leptin; thyroid function; beta-thalassemia.
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]]> 8141 An evaluation of blood glucose and lipid profile in female hypothyroidism patients in Kerbala province, Iraq https://ams.uokerbala.edu.iq/wp/en/blog/2023/06/07/an-evaluation-of-blood-glucose-and-lipid-profile-in-female-hypothyroidism-patients-in-kerbala-province-iraq/ Wed, 07 Jun 2023 07:37:55 +0000 http://ams.uokerbala.edu.iq/wp/en/?p=8134 An evaluation of blood glucose and lipid profile in female hypothyroidism patients in Kerbala province, Iraq ABSTRACTIntroduction and Aim: Hypothyroidism is a common metabolic disorder caused by inadequate secretion of the thyroid hormone by the thyroid glands. The condition impacts various metabolic processes including glucose synthesis, lipid synthesis, mobilization and metabolic rate. This study aimed […]

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An evaluation of blood glucose and lipid profile in female hypothyroidism patients in Kerbala province, Iraq

ABSTRACT
Introduction and Aim: Hypothyroidism is a common metabolic disorder caused by inadequate secretion of the thyroid hormone by the thyroid glands. The condition impacts various metabolic processes including glucose synthesis, lipid synthesis, mobilization and metabolic rate. This study aimed to evaluate the physiological factors associated with female hypothyroidism patients of Kerbala province of Iraq.
Materials and Methods: Fifty females (35 with hypothyroidism and 15 normal) aged between 20-49 years were included in the study. Blood sample was collected from each individual and subjected to thyroid function test (TFT), lipid profile test (LPT) and fasting blood glucose (FBG).
Results: The study showed a significant (P≤0.001) increase in thyroid stimulating hormone (TSH) levels as compared to control. While a significant decrease was seen in thyroxin (T4) levels in comparison to controls, no significant difference was seen for triiodothyronine (T3) levels in both groups. Low‑density lipoprotein (LDL), Triglycerides (TG), total cholesterol (TC) was significantly increased (P≤0.001) while high density lipoprotein (HDL) was observed to significantly decrease as compared to control group. High significant elevation (P≤0.001) in fasting blood glucose (FBG) was seen in patients with hypothyroidism as compared to control.
Conclusion: The results obtained in this study show that hypothyroidism in females to be significantly associated with increase in dyslipidemia and blood glucose levels.
Keywords: Hypothyroidism; blood glucose; lipid profile; glycemic status; Kerbala.
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]]> 8134 Hormonal studies of some herbs medicine extract (Salvia Officinalis) and its effect on total body weights and some reproductive organs in the mature female mice https://ams.uokerbala.edu.iq/wp/en/blog/2023/06/07/hormonal-studies-of-some-herbs-medicine-extract-salvia-officinalis-and-its-effect-on-total-body-weights-and-some-reproductive-organs-in-the-mature-female-mice/ Wed, 07 Jun 2023 06:14:08 +0000 http://ams.uokerbala.edu.iq/wp/en/?p=8117 Hormonal studies of some herbs medicine extract (Salvia Officinalis) and its effect on total body weights and some reproductive organs in the mature female mice Abstract:Present investigation was designed to show the influence of quotation of Salvia officinalis onsome reproductive organs for female mice. Three groups of this animals (6each) treated orallywith quotation of the […]

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Hormonal studies of some herbs medicine extract (Salvia Officinalis) and its effect on total body weights and some reproductive organs in the mature female mice

Abstract:
Present investigation was designed to show the influence of quotation of Salvia officinalis on
some reproductive organs for female mice. Three groups of this animals (6each) treated orally
with quotation of the herb in two different doses (30 and 60 mg/kg) respectively for four weeks.
The present study showed significant differences (P≤0.05) in body weight for both groups as
compared to control group, also significant differences (P≤0.05) in ovary and uterus only in the
group treated with high dose as compared to control group. However significant differences
(P≤0.05) found in reproductive hormone (FSH, LH) for both groups treated with Salvia officinalis
as compared to control group. Histological study showed a remarkable increase in number of
ovarian follicles, increase growth and development of oocyte and zona granulosa for groups
treated with Salvia officinalis as compared to control group.
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]]> 8117 Non-neoplastic MultinodularGoiterHisto Pathological Study https://ams.uokerbala.edu.iq/wp/en/blog/2023/06/07/non-neoplastic-multinodulargoiterhisto-pathological-study-2/ Wed, 07 Jun 2023 06:07:06 +0000 http://ams.uokerbala.edu.iq/wp/en/?p=8107 Non-neoplastic Multinodular GoiterHisto Pathological Study AbstractThe present Study carried_out on (15)Patients from males(30-60)year old,suffering from Goiter.the Patients conducted to medical and labatory examinations. The level of hormonesTSH,T4 and T3 was measured,the readings (0.31+0.2,13.24+0.30,240+6.5) on respectively when compared with control group.The histo-pathological results was revealed,enlargement in some thyroid follicles,and changes which occurs in the epithelial lining […]

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Non-neoplastic Multinodular GoiterHisto Pathological Study

Abstract
The present Study carried_out on (15)Patients from males(30-60)year old,suffering from Goiter.the Patients conducted to medical and labatory examinations. The level of hormonesTSH,T4 and T3 was measured,the readings (0.31+0.2,13.24+0.30,240+6.5) on respectively when compared with control group.
The histo-pathological results was revealed,enlargement in some thyroid follicles,and changes which occurs in the epithelial lining and converted to simple squamous epithelium, and some thyroid follicles was devoid from colloid with congestion in interstitial,blood vessels.the diameter of thyroid follicles in the goiter patient was (2.6+0.54)micromter when compared with control group (0.6+0.1) micrometer.
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]]> 8107 The study of some effect on happened rate of diabete mellite,in children in kerbala and Najaf(2010-2011) Read More https://ams.uokerbala.edu.iq/wp/en/blog/2023/06/07/the-study-of-some-effect-on-happened-rate-of-diabete-mellitein-children-in-kerbala-and-najaf2010-2011-read-more/ Wed, 07 Jun 2023 05:59:29 +0000 http://ams.uokerbala.edu.iq/wp/en/?p=8097 The study of some effect on happened rate of diabete mellite,in children in kerbala and Najaf(2010-2011) AbstractThis study condected to perform on numbers of children with Diabetes mellitus in age between less than year to more than five year in Karbala and Najaf city for year (2010 – 2011 ), the Total number of state […]

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The study of some effect on happened rate of diabete mellite,in children in kerbala and Najaf(2010-2011)

Abstract
This study condected to perform on numbers of children with Diabetes mellitus in age between less than year to more than five year in Karbala and Najaf city for year (2010 – 2011 ), the Total number of state in Karbala for year 2010 was (805) , (435) for boys (370) for girls and the number of state for (2011 ) is ( 888) , ( 459) for boys,(429)for girls . while the number of state in Najaf for gear (2010) was ( 140) state , (78) for boys (62) for girls while the number of state to the same city
for year (2011) was (77) state (40) for boys and (37) for girls . The study showed no significant differences between sexual for two city in two years . but study showed significant differences(p≤0.01) in the age facter in all state and the highest state record in the age more than 5 year in Karbala for year 2011 reach to ( 612 . 67± 31.79) twen year 2010 ( 436.00± 17.32 ) in Najaf the highest state record also in the age more than 5 year in the year (2010) then (2011) , (19.00± 5.19 ) and (47.00± 2.30 ) respectively . also showed significant differences in Karbala for two year than Najaf city for child Diabetes infection
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]]> 8097 Some Physiological Tests For Patients With Cutaneous Leish- maniasis in The Holy Karbala Province https://ams.uokerbala.edu.iq/wp/en/blog/2023/06/07/some-physiological-tests-for-patients-with-cutaneous-leish-maniasis-in-the-holy-karbala-province/ Wed, 07 Jun 2023 05:49:29 +0000 http://ams.uokerbala.edu.iq/wp/en/?p=8084 Some Physiological Tests For Patients With Cutaneous Leishmaniasis in The Holy Karbala Province AbstractLeishmaniasis is a common parasitic disease that affects dogs, wild rodents and humans that causes health problems for its effect on the individual’s health and psychology. The disease is transmitted by a disease vector called sand fly.In the present study30 samples were […]

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Some Physiological Tests For Patients With Cutaneous Leishmaniasis in The Holy Karbala Province

Abstract
Leishmaniasis is a common parasitic disease that affects dogs, wild rodents and humans that causes health problems for its effect on the individual’s health and psychology. The disease is transmitted by a disease vector called sand fly.
In the present study30 samples were taken from people infected with cutaneous leishmaniasis (12 females and 18 males) and (10) healthy individuals as a control group. The samples were collected from (1/9/2016) to (1/2/2017). The mini Vidas
device were used to examine the (TSH,T3,T4.GH) and the haemacounter devise used to count the (WBC, Lymphocytes, neutrophil. Results showed significant differences (p≤ 0.001) between males and females, while there were nosignificant
differences in age… However, the levels of GH, TSH and T3 were significantly different as compared to the control group… On other hand, no significant differences in the level of T4 hormone were compared to the control group. WBC counts were significantly different (p≤ 0.002) as compared to the control group.
While, there were no significant differences in the count of (neutrophils and lymphocytes) as compared to the control group. The study found the infection by cutaneous leishmaniasis did not have arisk for hormones levels that measured by
searching with confidence level (95%).
Keywords
Leishmaniosis, Cutaneous Leishmaniosis, TSH, T3, T4, GSH.
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]]> 8084 Toxic Effects of Prolonged Ni (II) and Cr (VI) Exposure in Male Mice on Bone Marrow and Some Hematological Parameters https://ams.uokerbala.edu.iq/wp/en/blog/2023/06/06/toxic-effects-of-prolonged-ni-ii-and-cr-vi-exposure-in-male-mice-on-bone-marrow-and-some-hematological-parameters-2/ Tue, 06 Jun 2023 09:36:31 +0000 http://ams.uokerbala.edu.iq/wp/en/?p=8078 Toxic Effects of Prolonged Ni (II) and Cr (VI) Exposure in Male Mice on Bone Marrow and Some Hematological Parameters AbstractHeavy metals hazard which can causes toxicological effects on many organs in animals and humans, therefore the purpose of the present study was to investigated the pathological lesion of Nickel (Ni II) and Chrome (Cr VI) metals […]

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Toxic Effects of Prolonged Ni (II) and Cr (VI) Exposure in Male Mice on Bone Marrow and Some Hematological Parameters

Abstract
Heavy metals hazard which can causes toxicological effects on many organs in animals and humans, therefore the purpose of the present study was to investigated the pathological lesion of Nickel (Ni II) and Chrome (Cr VI) metals on some hematological parameters in which heavy metal causes disorder in hematopoietic cell renewal system, which the results showed significant decrease (P≤0.01) in the red blood cells (RBC) count for all doses of Ni and Crelements, significant decrease (P≤0.05) in the monocytes cell counts only at intermediate and high dose of Ni and Cr elements while significant increase (P≤0.01) of granulocytes cell counts only at high dose for both Ni and Cr elements. Although the results demonstrated there was no any significant difference on platelets for all doses of Ni. On other hand no any
significant difference on platelets only at the lowest dose of Cr while, high significant differences (P≤0.01) on platelets at both intermediate and high dose of Cr. Also the results showed significant decrease (P≤0.05) in the bleeding time and clotting time for all groups treated with different doses of both Ni and Cr elements. Dramatic histological lesion for both
elements found in the tissue of bone marrow such as degenerate, necrotic and loosely arranged of tissue.
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]]> 8078 The toxic effect of nickel chloride (II) and potassium dichromate (VI) on the activity of reproductive system in male mice https://ams.uokerbala.edu.iq/wp/en/blog/2023/06/06/the-toxic-effect-of-nickel-chloride-ii-and-potassium-dichromate-vi-on-the-activity-of-reproductive-system-in-male-mice-3/ Tue, 06 Jun 2023 08:27:45 +0000 http://ams.uokerbala.edu.iq/wp/en/?p=8069 The toxic effect of nickel chloride (II) and potassium dichromate (VI) on the activity of reproductive system in male mice Abstract:Increase distribution of heavy metal and its compound in the environment, especially through anthropogenic and natural activity, raises increasing concern for toxicological effects. The present study was based on the fact that Ni and Cr […]

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The toxic effect of nickel chloride (II) and potassium dichromate (VI) on the activity of reproductive system in male mice

Abstract:
Increase distribution of heavy metal and its compound in the environment, especially through anthropogenic and natural activity, raises increasing concern for toxicological effects. The present study was based on the fact that Ni and Cr elements are important as the environmental factor produce the male genital system abnormalities. 35 male mice (10 weeks old) were randomly divided into seven groups 5 animals for each group, group 1 served as control received tap water, group 2,3 and 4 received (20, 40, and 60 mg/kg of Nicl2 respectively), while group 5,6 and 7 received (20, 60, and 100 mg/kg of K2Cr2O7 respectively). The results showed a high significant decrease (P≤0.0001) in the sperm count of male mice for intermediate and high dose treated with Nicl2 (II) as compared with control group, while no any significant differences between the lowest doses as compared with control group. The result showed a high significant difference (P≤0.0001) in the percentage of sperm abnormalities for intermediate and high dose treated with Nicl2 (II) as compared with control group.
Also the result showed a high significant difference (P≤0.0001) in the sperm count for all groups treated with different doses of K2Cr2O7 (VI) as compared with control group. About percentage of sperm abnormalities the result showed a high significant difference (P≤0.0001) in the percentage of sperm abnormalities for intermediate and high dose treated as compared with control group. 
Key words: potassium dichromate, nickel chloride and testicular toxicity,
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]]> 8069 The effects of Heavy metal (Nickel) on Hematological parameters of laboratory male mice https://ams.uokerbala.edu.iq/wp/en/blog/2023/06/06/the-effects-of-heavy-metal-nickel-on-hematological-parameters-of-laboratory-male-mice-3/ Tue, 06 Jun 2023 07:48:21 +0000 http://ams.uokerbala.edu.iq/wp/en/?p=8056 The effects of Heavy metal (Nickel) on Hematological parameters of laboratory male mice Abstrict The present study is aimed to investigate the hematological parameters such as hemoglobin(Hb), red blood cells (RBC), white blood cells (WBC), packed cell volume (PCV), mean cell volume (MCV), mean cell hemoglobin (MCH) and mean cell hemoglobin concentration (MCHC) in the blood of laboratory male […]

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The effects of Heavy metal (Nickel) on Hematological parameters of laboratory male mice

Abstrict
The present study is aimed to investigate the hematological parameters such as hemoglobin(Hb), red blood cells (RBC), white blood cells (WBC), packed cell volume (PCV), mean cell volume (MCV), mean cell hemoglobin (MCH) and mean cell hemoglobin concentration (MCHC) in the blood of laboratory male mice exposed to sub-lethal concentration of nickel chloride (NiCl2, 6H2O). The present study shows that the level of hemoglobin, red blood cells and packed cell volume were significantly decreased and simultaneously the white blood cells, mean cell volume, mean cell hemoglobin and mean cell
hemoglobin concentration were significantly decreased due to nickel exposure. The present study concluded that the nickel compound affects the hematological parameters of mice by received contaminated water.
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]]> 8056 Physiological and epidemiologic study for Mycobacterium tuberculosis in Kerbala Al Mukadssa https://ams.uokerbala.edu.iq/wp/en/blog/2023/06/06/physiological-and-epidemiologic-study-for-mycobacterium-tuberculosis-in-kerbala-al-mukadssa-2/ Tue, 06 Jun 2023 07:38:26 +0000 http://ams.uokerbala.edu.iq/wp/en/?p=8046 Physiological and epidemiologic study for Mycobacterium tuberculosis in Kerbala Al Mukadssa AbstractThis study condected to investigates of Mycobacterium tuberculosis from January till december 2007 from primary of care chest in Kirbala province , Atotal number collecting 339 (196 male &143 female).the study showed of infection with TB according to the months the higher percentage recorded […]

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Physiological and epidemiologic study for Mycobacterium tuberculosis in Kerbala Al Mukadssa

Abstract
This study condected to investigates of Mycobacterium tuberculosis from January till december 2007 from primary of care chest in Kirbala province , Atotal number collecting 339 (196 male &143 female).the study showed of infection with TB according to the months the higher percentage recorded in April then February reached (0.76,0.75) respectively. Also the affect of sex with infection disease showed high in male compared with female (0.55,0.43)respectively the study showed also active the highest according to another type ofTB (0.85) the study showed relation between age and percentage of infection and found the redy of infection in the age under 34 years old.
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