{"id":11569,"date":"2025-03-25T15:01:19","date_gmt":"2025-03-25T12:01:19","guid":{"rendered":"https:\/\/ams.uokerbala.edu.iq\/wp\/en\/?p=11569"},"modified":"2025-03-25T15:01:20","modified_gmt":"2025-03-25T12:01:20","slug":"treatment-autosomal-dominant-polycystic-kidney-disease","status":"publish","type":"post","link":"https:\/\/ams.uokerbala.edu.iq\/wp\/en\/blog\/2025\/03\/25\/treatment-autosomal-dominant-polycystic-kidney-disease\/","title":{"rendered":"Treatment-Autosomal dominant polycystic kidney disease"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Contents<\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nhs.uk\/conditions\/autosomal-dominant-polycystic-kidney-disease-adpkd\/\">Overview<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nhs.uk\/conditions\/autosomal-dominant-polycystic-kidney-disease-adpkd\/symptoms\/\">Symptoms<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.nhs.uk\/conditions\/autosomal-dominant-polycystic-kidney-disease-adpkd\/diagnosis\/\">Diagnosis<\/a><\/li>\n\n\n\n<li>Treatment<\/li>\n\n\n\n<li><a href=\"https:\/\/www.nhs.uk\/conditions\/autosomal-dominant-polycystic-kidney-disease-adpkd\/complications\/\">Complications<\/a><\/li>\n<\/ol>\n\n\n\n<p><strong>There&#8217;s currently no cure for autosomal dominant polycystic kidney disease (ADPKD), and it&#8217;s not possible to stop cysts forming in the kidneys.<\/strong><\/p>\n\n\n\n<p>But&nbsp;there are some potentially useful medications, such as tolvaptan, that can sometimes be used to reduce the growth rate of cysts.<\/p>\n\n\n\n<p>The various problems associated with ADPKD, such as&nbsp;<a href=\"https:\/\/www.nhs.uk\/conditions\/high-blood-pressure-hypertension\/\">high blood pressure (hypertension)<\/a>, pain and&nbsp;<a href=\"https:\/\/www.nhs.uk\/conditions\/kidney-stones\/\">kidney stones<\/a>, can also be treated.<\/p>\n\n\n\n<p>If you&#8217;re diagnosed with ADPKD, you&#8217;ll usually see a kidney specialist, who can help draw up a suitable treatment plan.<\/p>\n\n\n\n<p>The plan will also include what you&#8217;d want to do if your kidneys stop working sufficiently (kidney failure).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">High blood pressure<\/h2>\n\n\n\n<p>Medication is usually used to treat high blood pressure&nbsp;in people with ADPKD.<\/p>\n\n\n\n<p>Angiotensin-converting enzyme (ACE) inhibitors and angiotensin-2 receptor blockers (ARBs) are the 2 medications most widely used.<\/p>\n\n\n\n<p>There are also some lifestyle changes you can make to help reduce your blood pressure, such as cutting your&nbsp;<a href=\"https:\/\/www.nhs.uk\/live-well\/eat-well\/how-to-eat-a-balanced-diet\/tips-for-a-lower-salt-diet\/\">salt<\/a>&nbsp;intake to less than 6g a day (6g of salt is about 1 teaspoonful).<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nhs.uk\/conditions\/high-blood-pressure-hypertension\/treatment\/\">Find out more about treating high blood pressure<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pain<\/h2>\n\n\n\n<p>In many cases of ADPKD, any pain you experience can be relieved by treating the underlying cause, such as kidney stones or a&nbsp;<a href=\"https:\/\/www.nhs.uk\/conditions\/urinary-tract-infections-utis\/\">urinary tract infection (UTI)<\/a>.<\/p>\n\n\n\n<p>If you need to take a painkiller,&nbsp;<a href=\"https:\/\/www.nhs.uk\/conditions\/paracetamol\/\">paracetamol<\/a>&nbsp;is the best medication to try first.<\/p>\n\n\n\n<p>If your pain is particularly severe, you may be prescribed a stronger painkiller, such as tramadol or oxycodone.<\/p>\n\n\n\n<p>It&#8217;s usually recommended that&nbsp;<a href=\"https:\/\/www.nhs.uk\/conditions\/nsaids\/\">non-steroidal anti-inflammatory drugs (NSAIDs)<\/a>, such as&nbsp;<a href=\"https:\/\/www.nhs.uk\/conditions\/ibuprofen\/\">ibuprofen<\/a>, are avoided.<\/p>\n\n\n\n<p>This is because they could disrupt kidney function and interfere with medications prescribed to control your blood pressure.<\/p>\n\n\n\n<p>But a short course of NSAIDs may sometimes be safe for people with well-controlled blood pressure and relatively normal kidney function.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nhs.uk\/conditions\/antidepressants\/\">Antidepressants<\/a>&nbsp;or anticonvulsants, which are normally used to treat&nbsp;<a href=\"https:\/\/www.nhs.uk\/conditions\/epilepsy\/\">epilepsy<\/a>, may be prescribed for long-term (chronic) pain. These medications can also be used to relieve some types of pain.<\/p>\n\n\n\n<p>Occasionally, large cysts can be drained to help relieve the pain caused by the increased pressure.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Kidney stones<\/h2>\n\n\n\n<p>Small kidney stones pass out of your body when you urinate. If needed, you may be given a strong painkiller and medication to stop you feeling or being sick.<\/p>\n\n\n\n<p>Drinking plenty of water will increase the flow of urine, which will help flush the stone into the bladder.<\/p>\n\n\n\n<p>If a kidney stone is too big to be passed naturally, you may need&nbsp;treatment to help remove it.<\/p>\n\n\n\n<p>Possible treatment options include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>using energy waves to break the stone into smaller pieces (extracorporeal shock wave lithotripsy, or ESWL)<\/li>\n\n\n\n<li>passing\u00a0a thin telescopic instrument called a\u00a0ureteroscope up your urethra to remove or break up the stone<\/li>\n<\/ul>\n\n\n\n<p><a href=\"https:\/\/www.nhs.uk\/conditions\/kidney-stones\/treatment\/\">Find out more about treating kidney stones<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Urinary tract infections (UTIs)<\/h2>\n\n\n\n<p>Urinary tract infections (UTIs) can often be treated with a 7- to 14-day course of antibiotic tablets.<\/p>\n\n\n\n<p>You should drink plenty of fluids during the course of the infection to keep you hydrated.<\/p>\n\n\n\n<p>Paracetamol can be used to relieve pain and bring down your temperature.<\/p>\n\n\n\n<p>It&#8217;s important to see your GP as soon as possible if you develop&nbsp;<a href=\"https:\/\/www.nhs.uk\/conditions\/urinary-tract-infections-utis\/\">symptoms of a UTI<\/a>, as it could spread to the cysts in your kidneys if left untreated.<\/p>\n\n\n\n<p>Infection in the cysts is harder to cure because it can be difficult for the antibiotics to penetrate them.<\/p>\n\n\n\n<p>If the infection persists despite antibiotic treatment, the infected cysts may need to be drained during surgery or using&nbsp;a needle inserted through your skin.<\/p>\n\n\n\n<p>If you have severe, persistent or frequently recurring UTIs, you may need surgery to remove 1 or both of your kidneys, followed by dialysis or a kidney transplant.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Kidney failure<\/h2>\n\n\n\n<p>You&#8217;ll have blood tests at varying intervals to monitor your kidney function.<\/p>\n\n\n\n<p>You should discuss with your doctors what treatment you&#8217;d like&nbsp;if your condition reaches a stage where your kidneys stop working altogether (kidney failure).<\/p>\n\n\n\n<p>The 2 main treatment options for kidney failure are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.nhs.uk\/conditions\/dialysis\/\">dialysis<\/a>,\u00a0where a machine replicates some of your kidneys&#8217; functions<\/li>\n\n\n\n<li>a kidney transplant, where a healthy kidney is removed from a living or recently deceased\u00a0donor and implanted into someone with kidney failure<\/li>\n<\/ul>\n\n\n\n<p>You only need 1 kidney to survive. This means that unlike other types of organ donation, a living person can donate a kidney.<\/p>\n\n\n\n<p>Close relatives usually make the best match, so you may want to see if a relative would consider being tested to find out whether they&#8217;re a suitable donor.<\/p>\n\n\n\n<p>A few people with kidney failure decide not to have dialysis or a kidney transplant, preferring simple treatment of their symptoms.<\/p>\n\n\n\n<p>For example, a person may choose this option&nbsp;if it&#8217;s unlikely that&nbsp;dialysis will significantly prolong their life or improve their quality of life.<\/p>\n\n\n\n<p>If this choice is made, supportive treatment to help control symptoms will be provided to make the end of life as comfortable as possible.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Tolvaptan<\/h2>\n\n\n\n<p>Tolvaptan is a medication that&#8217;s recommended by the National Institute for&nbsp;Health and Care Excellence (NICE) to treat ADPKD in adults.<\/p>\n\n\n\n<p>It can be used to slow down the growth of cysts, reducing overall kidney growth and preserving kidney function for longer.&nbsp;<\/p>\n\n\n\n<p>But tolvaptan can only be used&nbsp;in adults who have:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>chronic kidney disease (stage 2 or 3)\u00a0at the start of treatment<\/li>\n\n\n\n<li>evidence of rapidly progressing kidney disease<\/li>\n<\/ul>\n\n\n\n<p>Tolvaptan comes in tablet form and is taken twice a day as a split dose.<\/p>\n\n\n\n<p>Common side effects include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>thirst<\/li>\n\n\n\n<li>the need to pee frequently<\/li>\n\n\n\n<li>the need to pass urine at night<\/li>\n<\/ul>\n\n\n\n<p>Chemical-related liver damage (hepatotoxicity) has also been reported in some people taking tolvaptan for ADPKD.<\/p>\n\n\n\n<p>If you&#8217;re taking tolvaptan, you&#8217;ll need to initially be monitored frequently through hospital clinics.<\/p>\n\n\n\n<p>You can read more about the use of&nbsp;<a href=\"https:\/\/bnf.nice.org.uk\/drugs\/tolvaptan\/\">tolvaptan for treating ADPKD<\/a>&nbsp;on the BNF website.&nbsp;&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Avoiding injury<\/h3>\n\n\n\n<p>If you have ADPKD, your kidneys will be more vulnerable to injury. For example, a sudden knock or blow to your kidneys could cause the cysts to split and bleed, leading to severe and intense pain.<\/p>\n\n\n\n<p>Avoiding all types of contact sport, such as rugby and football, is usually recommended.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Contents There&#8217;s currently no cure for autosomal dominant polycystic kidney disease (ADPKD), and it&#8217;s not possible to stop cysts forming in the kidneys. But&nbsp;there are some potentially useful medications, such as tolvaptan, that can sometimes be used to reduce the growth rate of cysts. The various problems associated with ADPKD, such as&nbsp;high blood pressure (hypertension), [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":[],"rop_publish_now_history":[],"rop_publish_now_status":"pending","_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"","ocean_second_sidebar":"","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"","ocean_custom_header_template":"","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"","ocean_menu_typo_font_family":"","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"","ocean_post_oembed":"","ocean_post_self_hosted_media":"","ocean_post_video_embed":"","ocean_link_format":"","ocean_link_format_target":"self","ocean_quote_format":"","ocean_quote_format_link":"post","ocean_gallery_link_images":"on","ocean_gallery_id":[],"footnotes":""},"categories":[117],"tags":[],"class_list":["post-11569","post","type-post","status-publish","format-standard","hentry","category-medical-information","entry"],"aioseo_notices":[],"jetpack_featured_media_url":"","rttpg_featured_image_url":null,"rttpg_author":{"display_name":false,"author_link":"https:\/\/ams.uokerbala.edu.iq\/wp\/en\/blog\/author\/ams0manager\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/ams.uokerbala.edu.iq\/wp\/en\/blog\/category\/medical-information\/\" rel=\"category tag\">Medical Information<\/a>","rttpg_excerpt":"Contents There&#8217;s currently no cure for autosomal dominant polycystic kidney disease (ADPKD), and it&#8217;s not possible to stop cysts forming in the kidneys. But&nbsp;there are some potentially useful medications, such as tolvaptan, that can sometimes be used to reduce the growth rate of cysts. The various problems associated with ADPKD, such as&nbsp;high blood pressure (hypertension),&hellip;","_links":{"self":[{"href":"https:\/\/ams.uokerbala.edu.iq\/wp\/en\/wp-json\/wp\/v2\/posts\/11569","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ams.uokerbala.edu.iq\/wp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ams.uokerbala.edu.iq\/wp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ams.uokerbala.edu.iq\/wp\/en\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/ams.uokerbala.edu.iq\/wp\/en\/wp-json\/wp\/v2\/comments?post=11569"}],"version-history":[{"count":1,"href":"https:\/\/ams.uokerbala.edu.iq\/wp\/en\/wp-json\/wp\/v2\/posts\/11569\/revisions"}],"predecessor-version":[{"id":11585,"href":"https:\/\/ams.uokerbala.edu.iq\/wp\/en\/wp-json\/wp\/v2\/posts\/11569\/revisions\/11585"}],"wp:attachment":[{"href":"https:\/\/ams.uokerbala.edu.iq\/wp\/en\/wp-json\/wp\/v2\/media?parent=11569"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ams.uokerbala.edu.iq\/wp\/en\/wp-json\/wp\/v2\/categories?post=11569"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ams.uokerbala.edu.iq\/wp\/en\/wp-json\/wp\/v2\/tags?post=11569"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}