ROLE OF IL10,TNF IN IRAQI PATIENTS WITH COLON CANCER
ABSTRACT
Colorectal cancer (CRC) is the third most commonly diagnosed cancer among
males and the fourth most common among females worldwide. investigated the
serum levels of IL-10 and TNF-α in patients with colon cancer. Fifty patients with
colon cancer (21 female and 29 male) with ages ranged between (20-70) years were
taken from (Al-Hussain Hospital City/Kerbala, Digestive and Liver Disease
/Education Hospital Medical City Baghdad and Teaching Oncology Hospital
/Baghdad Medical City/ Baghdad /Iraq).Control group consisted of 20 healthy
people who were free from signs and symptoms of cancer who matched in age and
gender with patients, and had no history for any gastrointestinal problem.TNF-
α(TNF-α-EASIA Kit, DIAsource) and IL-10 (IL-10-EASIA Kit, DIAsource) were
studied using the enzyme-linked immunosorbent assay (ELISA) method.t-test and
ANOVA and Pearson correlation used to analyze results by using SPSS version 19.
P-value ≤ 0.05 was considered significant.Serum CEA,Ca19-9 ,IL10 and TNF- α
were increased significantly (p< 0.05) in patients compared with control
group,these parameters increased no significantly (p>0.05) after chemotherapy
except IL-10,so increasing of CEA,Ca19-9,IL-10,and TNFα values at
stage3(10.3±3),stage1 (52±9.5),stage4(49±23)stage1(148±16) respectively no
significant(p>0.05) among stages, the results revealed a strong correlation (p<0.05)
between TNF and CA19.While there is no significantly correlation (p<0.05) found
in the studying parameters in patients who did not treatment with chemotherapy
drug. Significantly correlation of CEA,Ca19-9 ,IL10 and TNF- α with colon cancer,
so increased no significantly (p>0.05) after chemotherapy except IL-10.
