Antibacterial Activity of Copper Oxide Nanoparticles Against Methicillin Resistant Staphylococcus Aureus (Mrsa)
ABSTRACT
One hundred wound swab samples were collected from wound patients who visited in the Teaching Hospital Wound Unit in Hillah, Babylon Province, Iraq. S. aureus was identified morphologically and biochemically. Total of 30 (30%) from total samples exhibited positive culture for S. aureus. Out of 30 S. aureus, 8 (26.6%) isolates were Methicillin-resistant S. aureus (MRSA); Antibiotic susceptibility was tested for eight antibiotics for MRSA that appeared sensitive toward tetracycline, rifampin and ciprofloxacin (62.5%) but (37.5%) were resistant. For penicillin G and cefoxitin, all isolates were resistant (100%). For Clindamycin, (25%) of isolates were resistant, but (75%) were sensitive. About (62.5%) were resistant to Erythromycin, but (37.5%) were sensitive. Isolates showed resistance to Gentamycin in 50% and 50% sensitive. Anti-bacterial activity of copper oxide nanoparticles (CuO NPs) against S. aureus displays excessive widespread spectrum antibacterial action against established bacteria with increase zone of inhibition diameter that is proportional to the increase in nanoparticle concentration. The MIC of CuO NPs ranged from 75–150μg/mL, and the MBC ranged from 150-300μg/mL. CuO NPs is recommended as an efficient anti-MRSA alternative.
Keywords: CuO, Nanoparticles, S. aureus, MRSA.
