Abstract
Background: : Hypothyroidism is associated with an increase in the levels of thyroid releasing hormone (TRH) which in turn stimulates secretion of thyroid stimulating hormone (TSH) and prolactin (PRL). PRL suppresses gonadotropin synthesis and secretion (FSH & LH) Hormone insufficiency is the primary cause of hypothyroidism The severity of severe or clinical hypothyroidism and mild or subclinical hypothyroidism is classified as congenital or acquired, depending on the level of endocrine dysfunction in primary, secondary, or central, and the severity of severe or clinical hypothyroidism. Hypothyroidism can influence fertility by disrupting sex hormone balance, ovulatory cycles, luteal phase, hyperprolactinemia, or miscarriage. Methods: The study includes 100 patients clinically diagnosed with hypothyroidism. Three study groups have been investigated: (41 clinical hypothyroid patients, 19 subclinical hypothyroid patients 40 healthy individuals) of age (18-45) years. The aim of the study was to determine the levels of LH, FSH, TSH, T3, T4 and prolactin from the serum of infertile women in Samarra city, and to explain the relationship between hormone levels and the possibility of its impact on fertility. Results: The results showed a significant difference at (P≤ 0.05 ) between levels of LH , FSH of hypothyroidism women as compared with intact group. The results also showed a significant difference at (P<0.05) of (TSH, T3, T4) of hypothyroidism women as compared with intact; there were significant differences at ( P<0.05) of (prolactin) level between hypothyroidism women & intact. Conclusion: Hypothyroidism can have an important effect on reproductive hormones. Biochemical for fertility dysfunction is critical in all hypothyroidism patients.
Keywords: Hypothyroidism, LH, FSH , Thyroid hormone
