Effect of bisphenol-A- on some immunological parameters of female rats (Rattus Norvegicus)

Bisphenol-A-(BPA) is one of endocrine disruptor substances. The present study was conducted to investigate effect of BPA on some immunological parameters such as interleukin-1β (IL-1β),interleukin-6(IL-6),interleukin-2(IL-2), tumor necrotic factor-α(TNF-α),complememt3 (C3) and Immunoglobulin G (IgG).Twenty four female rats were used and divided into three groups (8 animals for each group) randomly. Animals of first group was negative control group and second group was positive control group received normal saline and corn oil orally respectively, while female rat of third group were received BPA suspended with corn oil (250mg/kg B.W/day) orally as treatment group for 30 days . Results of the present study revealed significant increase (P≤0.05) in serum level of (IL-1β, IL-6, IL-2, TNF-α, C3 and IgG) in group administrated BPA in compared with all other groups.
Keywords: bisphenol-A-, IL-6, TNF-α, rat