Evaluation of IgG and IFN-γ generated after vaccination with Pfizer in persons residing in Kerbala province, Iraq

The SARS-CoV2 vaccines are safe and smart way to protect ourselves. Once the body takes one or more doses of the vaccine, it produces an immune response without being fully exposed to the disease. It is important to evaluate the immune response generated against vaccine. So, the aim of the study was measuring the level of IgG and IFN-γ levels and study the differences their levels according to some risk factors like age, sex, previous infection, and BMI. that done by Cross-sectional study, where it was conducted between November 2021 and April 2022. Serum samples were obtained from 105 vaccinated persons with Pfizer. SARS-CoV-2 IgG levels and IFN-γ were detected. And the results obtain were the participants’ ages ranged from (18-72) years, they were divided into 2 groups: those under 25 years old 66 (62.9%), and those over 25 years old 39 (37.1%). 56 subjects (53.3%) were males and 49 (46.7%) were females. The sample was taken at various times and weeks. 50 individuals (74.6%) had received one dose, while the others 55 (52.4%) had received two doses, Additionally, 39 subjects (37.1%) had a confirmed infections prior to receiving the vaccine whereas others did not 66 (62.9%). Furthermore, according to BMI, 63 subjects (60%) had a normal weight and 29 (27.6%) had overweight, finally this study Concluded that younger participants under the age of 25 had higher antibody and IFN γ concentrations. higher antibody level and lower IFN γ in males than females were observed. Previous infection with covid 19 seems to have no effect on antibody and IFN γ level after vaccination with Pfizer.
Keywords: COVD19 vaccine, IgG concentration, IFN γ concentration, Pfizer