ABSTRACT
Introduction and Aim: Hypothyroidism is a common metabolic disorder caused by inadequate secretion of the thyroid hormone by the thyroid glands. The condition impacts various metabolic processes including glucose synthesis, lipid synthesis, mobilization and metabolic rate. This study aimed to evaluate the physiological factors associated with female hypothyroidism patients of Kerbala province of Iraq.
Materials and Methods: Fifty females (35 with hypothyroidism and 15 normal) aged between 20-49 years were included in the study. Blood sample was collected from each individual and subjected to thyroid function test (TFT), lipid profile test (LPT) and fasting blood glucose (FBG).
Results: The study showed a significant (P≤0.001) increase in thyroid stimulating hormone (TSH) levels as compared to control. While a significant decrease was seen in thyroxin (T4) levels in comparison to controls, no significant difference was seen for triiodothyronine (T3) levels in both groups. Low‑density lipoprotein (LDL), Triglycerides (TG), total cholesterol (TC) was significantly increased (P≤0.001) while high density lipoprotein (HDL) was observed to significantly decrease as compared to control group. High significant elevation (P≤0.001) in fasting blood glucose (FBG) was seen in patients with hypothyroidism as compared to control.
Conclusion: The results obtained in this study show that hypothyroidism in females to be significantly associated with increase in dyslipidemia and blood glucose levels.
Keywords: Hypothyroidism; blood glucose; lipid profile; glycemic status; Kerbala.
