College of Pharmacy, University of Karbala discussed a master dissertation on the effect of OAT2B1 and CYP2C8 Transporter Metabolizing Enzyme genotypes on the response to Montelukast treatment in children with asthma by the postgraduate student, Mrs. Hasna Haider Muhammad.
The dissertation aimed at studying the effect of genetic polymorphisms of the OATP2B1 transporter and the enzyme (CYP2C8) on the response to Montelukast treatment.
The dissertation concluded that there were genetic polymorphisms in the carrier gene (OATP2B1 c.935G>A) and the Gene (Cyp2C8*1B g.-271C>A) in a sample of the Iraqi population and there was a significant association between the polymorphism (OATP2B1 c.935G>A) and the response to Montelukast.
